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We continued our collaboration with the science shop for language, education and communication. Together, we advised in a national project on refugees and self care of the health council GGD ; , following our previous research projects on refugees and drug information Milani 2001, Rahemy 2002, Sekhuis 2003, Wu, Geudeke 2004 ; . We also collaborated with ETOC in researching new possibilities to inform deaf patients about their medication4. Since deaf experience comparable barriers in accessing medication information by immigrants interesting cross-links could be made between different projects aiming at ethnic minorities. In 2005, we plan to develop an interdisciplinary approach were different target groups may benefit from the concept of a visual patient information leaflet as developed for the population of deaf patients. Process evaluation of the use of the CDrom with these visual patient information leaflets in practice will give us some clues which elements are successful and more widely applicable. Children and drugs In 2004 we started a new research project, concerning the risk communication and risk perception with regard to childhood vaccination. This project intends to examine the influence of these risk aspects on parents' focus on vaccination. The results should be implemented in the already available information, to give parents the possibility to base their decision on objective, reliable information. For the implementation of the information about OTC use for pregnant women we found an additional collaboration partner in WINAp, the scientific institute for Dutch pharmacists. End 2004 a brochure was published about OTC use during pregnancy and lactation5 . The brochure content was therefore updated and extended with information on OTC and lactation. Besides the two pro-active themes discussed above, a variety of other projects regarding drugs and pharmacy were performed. A brochure on gadolinium a MRI agent ; was published on behalf of a Dutch organization for people suffering form contrast media6. A WHO-report was written, concerning prescribing quality indicators 7, 8. Again many individual questions on pregnancy and medication were received, mostly concerning antidepressants. Also the continuous use of paracetamol during pregnancy led to a minor research project, because inflammation.
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The mean age of the total patient population was 31.9 years SD 8.2, range 18-53 ; . Twenty-nine patients were on their first admission and they had not been on neuroleptic medication before. The remaining 21 patients had been previously treated for at least one psychotic episode 3.24.5 episodes including the current one, range 1-26 ; , but they had been drug-free for at least three months prior to admission. The symptoms of the patients were rated with the 18-item Brief Psychiatric Rating Scale BPRS ; Bech et al 1986 ; , rating each item from 0 to 6 and nimodipine, for instance, 500 mg.
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Applying a multiplex PCR approach with four primers yielded amplication products for blaA for two biovar 1B phenotypic group 1B-III ; and several biovar 3 strains Table 2 ; . Altering the PCR conditions or incorporating a chloroform-phenol extraction of the templates yielded the same results. Most strains of biovar 1A, including all those of phenotypic group 1AI and one of four strains belonging to phenotypic group 1A-II, yielded faint bands in the 1500-bp region instead of the 479-bp products anticipated with blaA primers not shown and noroxin.

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Product Name MD 0727 MK 0859 pitavastatin NK-104 ; PLT 732 QC-BT16 R1593 R1658 R1664 ReversionexTM HE2200 ; rilapladib Lp-PLA2 inhibitor ; RWJ-800025 Sponsor Microbia Cambridge, MA Merck Whitehouse Station, NJ Daiichi Sankyo Pharma Parsippany, NJ Pilot Therapeutics Winston-Salem, NC Quark Biotech Fremont, CA Roche Nutley, NJ Roche Nutley, NJ Roche Nutley, NJ Hollis-Eden Pharmaceuticals San Diego, CA GlaxoSmithKline Philadelphia, PA Rsch. Triangle Park, NC Johnson & Johnson Pharmaceutical Research & Development Raritan, NJ Takeda Pharmaceuticals North America Lincolnshire, IL Pfizer New York, NY Indication hypercholesterolemia hyperlipidemia hypercholesterolemia, hyperlipidemia hypertriglyceridemia hyperlipidemia dyslipidemia dyslipidemia dyslipidemia hypercholesterolemia Development Status Phase I 617 ; 621-7722 Phase II 800 ; 672-6372 Phase III 973 ; 359-2600 in clinical trials 919 ; 991-5429 Phase II 510 ; 402-4020 Phase I 973 ; 235-5000 Phase II 973 ; 235-5000 Phase I 973 ; 235-5000 Phase II completed 858 ; 587-9333 Phase I 888 ; 825-5249 Phase I 800 ; 817-5286. William Wong, San Francisco Department of Public Health, USA Charlotte Kent, San Francisco Department of Public Health, USA Robert Kohn, San Francisco Department of Public Health, USA Jeffrey D. Klausner, San Francisco Department of Public Health, USA and norfloxacin. When an ophthalmologist sees a patient for a minor condition such as conjunctivitis that does not require a complete eye exam, providers are to use the appropriate office evaluation and management code. Providers are to use the following eye exam procedure codes with a diagnosis of ophthalmological disease or injury. If the client is seen by an ophthalmologist for a diagnosis of refractive error or to rule out a refractive error, the code 1-S0620 or 1-S0621 must be billed. Refractions are limited for clients younger than 21 years of age to once every state fiscal year September 1 through August 31 ; . For clients younger than 21 years of age, this limitation may be exceeded if any of the following situations apply and the claim documentation supports the situation: A diopter change of 0.5 or more A school nurse, teacher, or parent requests the eye exam Medical necessity Clients 21 years of age and older are allowed one eye exam for refractive error once every 24 months. For example, if the exam for refractive error occurs in May 2001, the client older than 21 years of age is eligible for another exam in June 2003. If a client is eligible for Medicare and Medicaid, the eye exam for a diagnosis of eye disease, injury, or aphakia 1-92002, 1-92004, 1-92012, or 1-92014 ; must be billed to Medicare in accordance with Medicare filing procedures. The refractive portion of the exam must be billed to Medicaid within 95 days of the eye refraction with a medical diagnosis. Medicare does not cross over the refractive portion of the eye exam to the Texas Medicaid Program. When billed correctly, providers receive three payments: Medicare's allowance for the eye exam A Medicare Medicaid payment crossover for the allowed deductible and coinsurance on the eye exam A Medicaid-only payment for the refractive portion of the exam Procedure code 1-92015 is used when billing for just the refraction on a client who is eligible for Medicaid and has Medicare. Use procedure code 1-92015 when the refraction is the only service performed when evaluating a patient with ocular disease.

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Approvals are pending for ZonegranTM and Neurobloc in the US and we are looking forward to launching these drugs. In 2000, we anticipate reviewing the outcome of phase II clinical studies for Antegren in the chronic treatment of both multiple sclerosis and inflammatory bowel disease. We are also developing a transdermal patch for our Parkinson's disease treatment, Permax, and a once-daily form of our spasticity drug, Zanaflex. Additionally, we are progressing the European registrations of Neurobloc, and Zonegran. Pending the necessary approvals, we expect to introduce these products in a number of key European markets throughout the period 2001-2003. Operations The major activity in 1999 was the expansion of our sales and marketing infrastructure in the US and Europe in preparation for the anticipated product launches in 2000. Our US salesforce numbers over five hundred sales professionals focused on the management of pain and neurological conditions. In Europe we added additional representatives as we continue to build our infrastructure in those markets. Planned expansion in the US and Europe will likely see the combined salesforce exceeding 1, 000 representatives by 2001. We were particularly pleased with the success of Zanaflex and Skelaxin in the US market and note that Naprellan and Permax performed well in highly competitive markets. Our diagnostic businesses exceeded revenue of $50 million for the first time in 1999 and we anticipate revenue exceeding $100 million within the next two years. The neurological diagnostic service compliments our sales and marketing efforts and extends the range of services that we provide to our core neurologist market. Drug Delivery We were pleased that American Home Products Corporation "AHP" ; filed its NDA for the oral form of Rapamune in late 1999. This is the first NDA filing of a product utilizing our novel NanoCrystalTM and viramune.

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Table 5: Efficacy Scores, Acute Period to --Baseline -- -Endpoint -Variables Analyzed Therapy n Mean SD Mean SD p-Values -- -- - - - --YMRS Olz 125 27.42 5.24 -13.36 8.78 .028 DVPX 123 27.92 6.58 -10.39 10.45 HAMD21 Olz DVPX 123 124 -4.92 -3.46 -1.44 -1.31 -0.35 -0.31 -1.28 -1.09 -14.14 -11.02 -5.14 -4.15 -1.95 -1.46 7.22 6.40 1.20.

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